Pharmaceutical Grade 99% Rapamycin Powder CAS 53123-88-9 Rapamycin

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Pharmaceutical Grade 99% Rapamycin Powder CAS 53123-88-9 Rapamycin

Pharmaceutical Grade 99% Rapamycin Powder CAS 53123-88-9 Rapamycin

  • Item No. Rapamycin
    MOQ 1 Gram
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 Rapamycin

 

Pharmaceutical Grade 99% Rapamycin Powder CAS 53123-88-9 Rapamycin

Rapamycin

 

 

 

Name: Rapamycin

C.A.S NO. : 53123-88-9

 

Molecular formula: C51H79NO13

 

Assay: Over 99%

Characteristic: White powder

 

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Rapamycin is a member of the macrolide immunosuppressant family and a FRAP inhibitor. Rapamycin exhibits binding and inhibitory actions to the FK506 binding protein (FKBP5) proline rotamase via simultaneous binding by FKBP12 and FRAP. FRAP (RAFT1) proteins exhibit homology to PI 4- and PI 3-kinases,which have PI 4-kinase and autophosphorylating activities.The rapamycin/FKBP complex does not inhibit the FRAP PI 4-kinase activity,but does inhibit FRAP autophosphorylation.

Rapamycin is unique in its ability to inhibit lymphokine induced cell proliferation at the G1 and S phase as well as an irreversible cellular arrest at the G1 phase in S. cerevisiae cells.

Rapamycin also exhibits selective signal blocking leading to the activation of p70/85 S6 kinase, which is potentially due to the inhibition of FRAP autophosphorylation or protein kinase activity. Angiogenesis inhibition is also exhibited,possibly through the inhibition of the Akt pathway. Rapamycin is an inhibitor of mTOR.


Rapamycin

 

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Rapamycin

 

 

Rapamycin is a triene macrolide antibiotic,which demonstrates anti-fungal,anti-inflammatory,anti-tumor and immunosuppressive properties.

Rapamycin has been shown to block T-cell activation and proliferation,as well as,the activation of p70 S6 kinase and exhibits strong binding to FK506 binding proteins.

Rapamycin also inhibits the activity of the protein,mTOR(mammalian target of rapamycin) which functions in a signaling pathway to promote tumor growth.

Rapamycin binds to a receptor protein (FKBP12) and the rapamycin/FKB12 complex then binds to mTOR and prevents interaction of mTOR with target proteins in this signaling pathway.


 

Rapamycin

 

Rapamycin (RAPA) is a novel macrolide immunosuppressant is now often used as a transplanted organ to maintain immunity drugs (especially kidney transplants), to mitigate the immune organ rejection after transplant surgery, but scientists it recently found another purpose: for the treatment of Alzheimer's disease (senile dementia).

Target of rapamycin (mTOR) as an intracellular kinases pathway abnormalities can induce a variety of diseases.

As rapamycin mTOR inhibitor targeting, to treat with this pathway is closely related to tumors, including renal cell carcinoma, lymphoma, lung cancer, liver cancer, breast cancer, neuroendocrine carcinoma and gastric cancer

 

Rapamycin

 

Rapamycin

  

 

Our Advantage

Rapamycin

Xi'an Macale Biotechnology Co., Ltd. was established in 2012. It is a high-tech professional and technical enterprise integrating R & D, production and sales. Located in the world-famous historical capital-the ancient city of Xi'an.

Macale's production base is located in Xi'an, Shaanxi. It covers an area of 35,000 square meters and a building area of 20,000 square meters. It relies on the natural rich plant resources in the mountainous areas and the production bases of Chinese medicinal materials and intermediates in southern Shaanxi. Currently it has three multi-functional plant extraction and purification production lines and one Pilot production line, a GMP production line, and a fully equipped laboratory. Macale Bio is equipped with various detection equipment such as atomic absorption spectrometry,gas chromatography,spectrophotometer,polarimeter,

automatic titrator, biochemical oxygen demand incubator, chemical oxygen demand incubator, high performance liquid chromatography Etc. to ensure product quality.

Macale's main products are plant extracts ,health products,

and pharmaceutical raw materials. Most of our products are derived from natural plants. Marketing services are available in many countries around the world, as well as Hong Kong, Macao and Taiwan regions. We have established a good and stable cooperative relationship with more than a hundred pharmaceutical,food,health products and daily chemical manufacturing companies and pharmaceutical raw material traders.

Rapamycin

Rapamycin

Rapamycin

Q1:Are you a manufacturer or trading company?

A: We are a manufacturer, welcome to visit us.

 

Q2: What's your MOQ?

A:It depends on different products, we accept sample order or provide free samples for your

   testing.

 

Q3: How to confirm the product quality before placing the order?

A:Sample could be provided, and we have inspection report issued by authoritative third-party

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Q4:Can you send products to my country?

A: Sure, we can, we have rich shipping experience to the whole world.

 

Q5: How about delivery time/method?

A: We usually ship within 1-3 working days after your payment.

    We can ship by door to door courier, by air, by sea, you could also use your own shipping

    agent, if u have.

 

Q6. How to solve after-sale disputes?

A: We accept Changing or refunding service if any quality problem, u can pay via Alibaba to

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Rapamycin

Business TypeTrading CompanyCountry / RegionShaanxi, China
Main ProductsAPI Raw Material,Vitamins,Cosmetics Raw,Plant extract,AntibioticsTotal Employees5 - 10 People
Total Annual RevenueBelow US$1 MillionYear Established2019
Certifications Product Certifications 
Patents Trademarks 
Main MarketsWestern Europe 25%
North America 15%
Eastern Europe 12%

Xi'an Macale Biotechnology Co., Ltd. was established in 2012. It is a high-tech professional and technical enterprise integrating R & D, production and sales. Located in the world-famous historical capital-the ancient city of Xi'an.
Macale's production base is located in Xi'an, Shaanxi. It covers an area of 35,000 square meters and a building area of 20,000 square meters. It relies on the natural rich plant resources in the mountainous areas and the production bases of Chinese medicinal materials and intermediates in southern Shaanxi. Currently it has three multi-functional plant extraction and purification production lines and one Pilot production line, a GMP production line, and a fully equipped laboratory. Macale Bio is equipped with various detection equipment such as atomic absorption spectrometry,gas chromatography,spectrophotometer,polarimeter,
automatic titrator, biochemical oxygen demand incubator, chemical oxygen demand incubator, high performance liquid chromatography Etc. to ensure product quality.
Macale's main products are plant extracts ,health products,
and pharmaceutical raw materials. Most of our products are derived from natural plants. Marketing services are available in many countries around the world, as well as Hong Kong, Macao and Taiwan regions. We have established a good and stable cooperative relationship with more than a hundred pharmaceutical,food,health products and daily chemical manufacturing companies and pharmaceutical raw material traders.
Macale Corporation adheres to the corporate tenet of "scientific rigor, pioneering and innovative, sincere cooperation". "
Macale's corporate philosophy: "Integrity first, customer first. Sincere unity, open up the future."
With the improvement of people's quality of life in the new century, along with the vigorous development of the life and health industry, Macale Bio is facing greater opportunities and challenges. We are confident to provide more comprehensive and better scientific and technical services for scientific researchers. Macale will not humiliate its mission and create the future with you!

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